Faculty

Greenwald head shot.jpeg — Mark Greenwald, Ph.D.

Mark Greenwald, Ph.D. is Professor (tenured), Gertrude Levin Endowed Chair in Addiction & Pain Biology, and Associate Chair for Research in the Dept. of Psychiatry and Behavioral Neurosciences (DPBN) at Wayne State University School of Medicine (WSU SOM). He directs the Substance Abuse Research Division, its Human Pharmacology Laboratory and outpatient treatment research in the DPBN. He is also Adjunct Professor in the Dept. of Pharmacy Practice, and a Scientific Member of the Karmanos Cancer Institute.
The NIH (especially NIDA) has continuously funded his research since 1996. Dr. Greenwald has been PI or Co-PI on numerous grants and industry contracts totaling >$35 million, and co-investigator and mentor on many other NIH-supported research and training projects totaling >$30 million.
His scientific portfolio focuses on pharmacological, environmental and individual-difference determinants of drug-seeking/use (in relation to persistence of drug use and relapse) and development of innovative mechanism-driven medication and neuromodulation treatments. His research focuses on opioid use disorder, but includes cannabis, cocaine, and nicotine use disorders, as well as the biology & treatment of pain conditions (e.g. peripheral neuropathy).
He educates healthcare professionals worldwide and medical students on the neurobiology of addiction, harm reduction, and treatment of substance use disorders.

Leslie Lundahl, Ph.D.

Dr. Lundahl is Professor (tenured) in the Dept. of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine. She is a fully licensed Clinical Psychologist with expertise and >20 years of experience in diagnostic assessment and treating substance use disorders.
Dr. Lundahl has led several NIDA-funded projects on cannabinoids to examine (1) use of a drug discrimination model to test medications for cannabis use disorder, e.g. whether oral THC (CB1 receptor agonist) alters discriminative stimulus effects of cannabis and choice to smoke cannabis; (2) specificity of cannabis cue-induced craving paradigm, e.g. whether oral THC altered cue-induced craving; (3) use of the antioxidant drug N-acetylcysteine to attenuate cannabis cue-induced craving and seeking behavior; and (4) effects of acute stress and drug cues on cannabis-seeking behavior. She is currently investigating the interaction of cannabidiol (CBD) with morphine on pain sensitivity, and the role of cannabinoids (THC and CBD) in managing PTSD symptoms and suicidality among military veterans. Dr. Lundahl also mentors a substantial number of trainees (e.g. psychiatry residents, masters-level clinical psychology students).

David Ledgerwood, Ph.D.

Dr. Ledgerwood is Professor (tenured) in the Dept. of Psychiatry and Behavioral Neurosciences at the Wayne State University School of Medicine, a licensed clinical psychologist, and Director of the Nicotine and Tobacco Research Division (https://tobacco.med.wayne.edu).
His research covers multiple types of addictions including gambling disorder, nicotine use disorder and various other substance use problems. He is an internationally recognized expert in the area of gambling disorder, and has published research on the etiology, clinical features, and treatment of this disorder. His recent research on nicotine use disorder includes studies of smoking cessation interventions, risk factors for smoking among young adults, and use of electronic cigarettes. He also has conducted several studies examining behavioral treatments for substance use disorders, particularly behavioral incentive (contingency management) approaches. His recent research has applied behavioral incentives to parents of teens in juvenile drug court, persons with HIV who want to quit smoking, and individuals living in rural recovery housing. Dr. Ledgerwood is also an investigator on State of Michigan funded studies to examine the use of cannabinoids to treat mental health symptoms among veterans with PTSD and suicidality.

**Eric Woodcock, Ph.D.**

Dr. Woodcock is an Assistant Professor (tenure-track) in the Dept. of Psychiatry and Behavioral Neurosciences (DPBN) at the WSU SOM. He is also an Adjunct Assistant Professor in the Dept. of Pharmacology and a Scientific Member of the Karmanos Cancer Institute. Dr. Woodcock completed his PhD training in Translational Neuroscience at WSU supported by predoctoral NRSA (F31 DA040369) and Thomas C. Rumble Fellowships. He completed his postdoctoral training at Yale University supported by a T32 training program (T32 DA022975) and Career Transition Award (K99 DA048125) before returning to WSU as faculty in 2021.
His research utilizes neuroimaging, behavioral pharmacology, and neuromodulation to investigate brain-behavior mechanisms that underlie drug addiction. In particular, Dr. Woodcock’s research focuses on better understanding factors that contribute to relapse with the overall goal of identifying novel treatment targets. Recent studies have used PET and fMRI/MRS to investigate the roles of stress and neuroinflammation on executive function, cue reactivity, and drug seeking behavior. Dr. Woodcock’s research is supported by multiple grants including from the National Institutes of Health (R00 DA048125), State of Michigan Cannabis Regulatory Agency, and Peter F. McManus Charitable Trust. He has been continuously funded by NIH since 2016 receiving F-, T-, K-, and R-type grant funding support.

Hilary Marusak, Ph.D.

Dr. Marusak completed her doctoral and postdoctoral training at WSU, funded by a NIMH Career Development award. She is a tenure-track Assistant Professor in the Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine. She is also an Adjunct Assistant Professor in the Merrill Palmer Skillman Institute for Child and Family Development, a Scientific Member of the Karmanos Cancer Institute and the CURES Center, and a Science Advisor for the nonprofit organization Kids Kicking Cancer.

Dr. Marusak runs the THINK lab (Trauma History Investigation of Neurodevelopment in Kids: https://wsuthinklab.mystrikingly.com), which studies the impacts of childhood environmental adversity (e.g. stress, interpersonal trauma, air pollution) on brain development, and neurodevelopmental mechanisms leading to anxiety/fear-based disorders. Dr. Marusak uses multiple techniques (e.g. fMRI, EEG, biomarkers, genetics, behavioral approaches) to investigate the role of the endocannabinoid system in fronto-cortical brain development, stress reactivity, and the effects of exercise, meditation, and cannabinoid (e.g. CBD) administration. Her research is supported by multiple grants from the State of Michigan Cannabis Regulatory Agency, NIMH (K01 MH119241, R01 MH132830), NICHD (R21 HD105882), and she mentors many trainees.

Research Staff

Nareen Sadik

Nareen graduated from Wayne State University in 2019 with a degree in Nutrition and Food Science. Following graduation, she worked in the Dept. of Psychiatry and Behavioral Neurosciences at WSU. She initially worked as a laboratory manager for a few years in a substance use pre-clinical laboratory, then transitioned into the role of DrugLab manager. Nareen plans to pursue Medicine in the upcoming years.

Heidi Aguas

Heidi graduated in 2021 from Wayne State University with a degree in Neuroscience and University Honors with a minor in Public Health. Prior to working as a full time research assistant (since 2020), she assisted Tabitha Moses in her project exploring how rTMS can be used to improve treatment for people with opioid use disorder. She also has experience as a Certified Nurse Assistant and Medical Assistant working extensively with chronic pain and traumatic brain injuries. In the future, Heidi is planning on becoming a physician.

Alyson Renock

Alyson graduated from WSU with honors in 2021 with her Bachelor's of Science in Honors Psychology and a minor in Biological Sciences. She plans to pursue a PhD in Clinical Neuropsychology at WSU following her research in industrial organizational psychology and substance use psychiatry. She is interested in research pertaining to neuropsychological correlates of trauma and their interactions with substance use, psychopathology, and rehabilitation. Following her education, she aspires to become a clinical psychologist.

Taylor Harrison

Taylor Harrison is currently a 3rd year undergraduate, pursuing a BS in Neuroscience and a BA in Spanish. She first volunteered in our lab prior to joining full-time, assisting graduate student Tabitha Moses in her research examining effects of rTMS on treatment outcomes for patients with opioid use disorder. Taylor also has experience as a Medical Assistant with knowledge of scribing and assisting during dermatologic examinations/procedures. Upon earning her undergraduate degrees, Taylor plans to pursue a PhD with aspirations of conducting her own studies on substance use disorders.

Monya Ali

Monya graduated from Wayne State University in 2023 with a degree in Public Health. Prior to transitioning as a full-time research assistant in May 2023, she volunteered in the lab, assisting Tabitha Moses with her research regarding the use of rTMS to improve treatment outcomes and reduce stress in individuals with opioid use disorder. Monya aspires to go to medical school and become a physician in the near future.

Mahmoud Hossami

Mahmoud graduated in 2023 from the University of Windsor with a Masters in Translational Health Sciences and a Bachelors in Biological Sciences with Thesis. Prior to working as a full-time research assistant, he has research experience in immunology and cancer research. Mahmoud is planning on pursuing a PhD in Clinical Sciences.

Current and Recent Graduate Students

TabithaMoses.R5MembershipChair.jpg — Tabitha Moses

MD/PhD Student in the Translational Neuroscience Program, supervised by Dr. Mark Greenwald. Tabitha successfully defended her dissertation in February 2023 and is completing her final two years of medical school, but still contributes to several ongoing projects.
Projects:
1) Distinguishing different types of negative consequences of heroin use
2) Race differences in substance use patterns among injection heroin users
3) Poly-substance use among regular heroin users
4) Genetic variation in behaviors and response to treatment in people with opioid use disorder
5) Survey of experiences obtaining naloxone
6) Education of medical students in substance use disorders and harm reduction techniques.
7) Effects of frontal-cortical repetitive transcranial magnetic stimulation (rTMS) on stress-related drug-seeking behavior and related phenotypes in individuals with opioid use disorder (dissertation)

Halle Thomas

Doctoral Student in Clinical Psychology, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.

Nicole Kouri

Nicole is a fifth year Wayne State University clinical psychology doctoral student, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.
She is interested in (1) the intersection of interpersonal violence, post-traumatic stress and dissociation, and addiction; and (2) how systems, whether familial or institutional, promote potentially maladaptive coping strategies. Nicole also specializes in statistics and is a consultant for Wayne State's Research Design and Analysis Unit.

Marjorie (Marisa) Heule

Doctoral Student in Clinical Psychology, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.

Projects:

Analysis of PATH tobacco data

Examination of how trauma and emotions intersect with chronic pain and opioid misuse

Medical Student Projects

DvA

***Students (***†***) supervised by Dr. Mark Greenwald***
**Alexa Kalaj**
Greenwald MK, Kalaj A†, Burmeister M, Roehrs TA (under review) Predictors of heroin-use circadian pattern: demographics, non-opioid substance use, and *CLOCK* genetic variation.
**Liam Browning**
Browning L†, Cannoy C†, Moses TEH†, Lundahl LH, Ledgerwood DM, Greenwald MK (under review) Childhood-onset attention-deficit/hyperactivity disorder exacerbates opioid use disorder consequences: mediation by impulsive phenotypes. *Drug and Alcohol Dependence*.
**Siri Sarvepalli**
Greenwald MK, Sarvepalli S†, Cohn JA, Lundahl LH (2021) Demand curve analysis of marijuana use among persons living with HIV. *Drug and Alcohol Dependence* 220: 108524.
**Mohammed Faraj**
Faraj MM†, Lipanski NM, Morales A, Goldberg E, Bluth M, Marusak HA, Greenwald MK (2021) A virtual reality meditative intervention modulates pain and the pain neuromatrix in patients with opioid use disorder. *Pain Medicine* 22(11): 2739-2753.
**Irene Chen and Danni Feng**
Woodcock EA, Greenwald MK, Chen I†, Feng D†, Cohn JA, Lundahl LH (in preparation) HIV chronicity as a predictor of hippocampal memory deficits in daily cannabis users living with HIV. *Drug and Alcohol Dependence Reports* 9: 100189.
**Nora Akcasu and Paige Baal**
Greenwald MK, Akcasu N†, Baal P†, Outlaw AY, Cohn JA, Lundahl LH (2021) Cannabis and complementary/alternative self-treatment approaches for symptom management among African American persons living with HIV. *AIDS Care* 35: 78-82.
**Shabber Syed and Lina Shkokani**
Greenwald MK, Lundahl LH, Shkokani L†, Syed S†, Roxas RS, Levy P (2021) Effects of cocaine and/or heroin use history on resting cardiovascular function. *International Journal of Cardiology: Cardiovascular Risk and Prevention* 11: 200123.
**Tabitha Moses, Luz Nagle, Anirudh Chitale, Jody Chou, Irvin Lien, May Chammaa, Sabrina Dass, Rafael Ramos, Kristina Barrientos, Lauren Culver, Kara Klomparens, Kelsey Gockman, et. al.**
*Several research projects on medical student education in substance use disorders, especially opioid overdose prevention and response training, e.g..*
Moses TEH†, Chou JS†, Moreno J, Lundahl LH, Waineo E, Greenwald MK (2021) Long-term effects of opioid overdose prevention and response training on medical student knowledge and attitudes toward opioid overdose: a pilot study. *Addictive Behaviors* 126: 107172.
Moses TEH†, Moreno JL, Greenwald MK, Waineo E (2021) Training medical students in opioid overdose prevention and response: comparison of in-person vs. online formats. Medical Education Online 26(1): 1994906.
Moses TEH†, Rhodes GL, Tavakoli E††, Christensen CW, Amirsadri A, Greenwald MK (2022) Predictors of retention and drug use among patients with opioid use disorder transferred to a specialty “Second Chance” methadone program. Substance Abuse: Research and Treatment 16: 1-11.
Moses TEH†, Waineo E, Levine D, Greenwald MK (2023) Optimizing buprenorphine training during undergraduate medical education: medical student feedback and attitudes. *The American Journal on Addictions* 32: 376-384.
Nagle LE†, Moses TEH†, Chitale A†, Chou JS†, Lien I†, Waineo E, Greenwald MK (2022) Building a strong foundation from the ground up: the impact of medical student substance use disorder organizations on curriculum and community. *Journal of Addictive Diseases* 41: 156-166.
***Students supervised by Dr. David Ledgerwood***
**Mark Zakrajsec**
Interaction between acute stress and delay discounting among current cigarette smokers.

Detroit vs. Addiction (medical student organization)

Alumni: Former Graduate Students and Research Staff

Shaylin Excell

Doctoral Student in Clinical Psychology, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.
Projects:
1) Analysis of PATH tobacco data
2) Systematic review of the Pathways model of problem gambling
3) Examination of cannabis and tobacco smoking correlates of COVID-19

Krithika Prakash

Doctoral Student in Clinical Psychology, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.
Projects:
1) Analysis of PATH tobacco data
2) Examination of cannabis and tobacco smoking correlates of COVID-19

Ciara Cannoy

Doctoral Student in Clinical Psychology, supervised by Dr. Leslie Lundahl and Dr. David Ledgerwood.
Projects:
1) Analysis of PATH tobacco data
2) Systematic review of the Pathways model of problem gambling
3) Examination of cannabis and tobacco smoking correlates of COVID-19

Nicole Zabik

Doctoral Student in the Translational Neuroscience Program, co-supervised by Dr. Christine Rabinak and Dr. Mark Greenwald. She graduated in 2022, and is currently a postdoctoral fellow at the University of Nebraska.
Projects:
1) Survey of self-management strategies among opioid users
2) Associations of cannabinoid genetic variations with opioid use patterns
3) Neural signature of fear-avoidance behavior

Alanna Foulon

Alanna graduated in 2022 from the University of Windsor with her BA Honors in Psychology with Thesis. She is presently pursuing a Masters in Clinical Social Work at Michigan State University and hopes to work with populations experiencing substance use disorders, mood disorders and PTSD.

Klevis Karavidha

**Research Assistant**
Klevis is a former student in the WSU Translational Neuroscience Program. He earned his M.S. degree in the Biomedical Sciences program. Subsequently, Klevis provided excellent service as the DrugLab manager. In July 2022, Klevis began medical school at Michigan State University.

Publication:
Karavidha K, Burmeister M, Greenwald MK (2021) Beta-arrestin2 (*ARRB2*) polymorphism associated with the adverse consequences of chronic heroin use. *The American Journal on Addictions* 30: 351-357. DOI: 10.1111/ajad.13150

Cecilia Li

Cecilia graduated from UCLA in 2018 with a Bachelor's of Science in Psychobiology. Prior to working as a research assistant, she worked in two different immunology research laboratories at UCSD, where she focused on inflammatory neurotoxicity contributing to Alzheimers's and stroke disease. She also has a wide range of patient care experience, including hospice care, doula birth work, free clinic management, and working with kids on the autism spectrum. Eventually, Cecilia plans to apply to medical school.